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Abstract #0189

A Prototype Image Quality Assurance System for Accelerated Quantitative Breast DCE-MRI

Yuan Le1, Aneela Afzal2, Xiao Chen3, Bruce Spottiswoode4, Wei Huang2, and Chen Lin1

1Radiology and Imaging Science, Indiana University School of Medicine, Indianapolis, IN, United States, 2Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, United States, 3Siemens Healthcare, Princeton, NJ, United States, 4Siemens Healthcare, Chicago, IL, United States

The goal of this work is to build a prototype quality assurance (QA) system for the quantitative pharmacokinetic (PK) analysis of breast DCE-MRI acquired with accelerated imaging techniques. A 3D digital tumor model with two sub-regions was constructed by segmenting patient images. The dynamic contrast enhanced images were synthesized according to the Tofts and Shutter Speed models with the TWIST technique. The QA system shows how the TWIST technique impacts the estimated pharmacokinetic parameters, and therefore allows necessary adjustments to be made to control the error.

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