Abstract #0189

A Prototype Image Quality Assurance System for Accelerated Quantitative Breast DCE-MRI

Yuan Le¹, Aneela Afzal², Xiao Chen³, Bruce Spottiswoode⁴, Wei Huang², and Chen Lin¹

¹Radiology and Imaging Science, Indiana University School of Medicine, Indianapolis, IN, United States, ²Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, United States, ³Siemens Healthcare, Princeton, NJ, United States, ⁴Siemens Healthcare, Chicago, IL, United States

The goal of this work is to build a prototype quality assurance (QA) system for the quantitative pharmacokinetic (PK) analysis of breast DCE-MRI acquired with accelerated imaging techniques. A 3D digital tumor model with two sub-regions was constructed by segmenting patient images. The dynamic contrast enhanced images were synthesized according to the Tofts and Shutter Speed models with the TWIST technique. The QA system shows how the TWIST technique impacts the estimated pharmacokinetic parameters, and therefore allows necessary adjustments to be made to control the error.

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