Abstract #0212

Detection of Microscopic Diffusion Anisotropy in Human Brain Cortical Gray Matter in Vivo with Double Diffusion Encoding

Marco Lawrenz¹ and Juergen Finsterbusch¹

¹Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Double diffusion encoding experiments with two weighting periods applied successively in the same acquisition offer access to microscopic tissue properties. Rotationally invariant measures of the so-called microscopic diffusion anisotropy as a marker for cell or compartment shape have reliably been determined in brain white matter. In this study, it is demonstrated that microscopic diffusion anisotropy can also be detected in cortical gray matter in vivo and measures of it can be determined extending first evidences presented recently. However, an inversion recovery pulse is required to null white matter signals and avoid partial volume effects.

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