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Abstract #0220

BOLD Hemodynamic alteration in Brain Tumors

Lalit Gupta1, Rakesh K Gupta2, Prativa Sahoo1, Pradeep K Gupta2, Rana Patir3, Sandeep Vaishya3, Indrajit Saha4, and Walter Backes5

1Philips India Ltd., Bangalore, India, 2Department of Radiology, Fortis Memorial Research Institute, Gurgaon, India, 3Department of Neurosurgery, Fortis Memorial Research Institute, Gurgaon, India, 4Philips India Ltd., Gurgaon, India, 5Department of Radiology, Maastricht University Medical Center, Maastricht, Netherlands

The objective of the study is to determine the temporal delay in cerebral hemodynamic flow in brain tumors relative to normal brain tissue using rsfMRI and compare this with DCE derived cerebral blood volume(CBV) maps. Time series from all the voxels were cross-correlated with the mean time series from the normal hemisphere. The time point with maximum correlation was used to generate temporal shift map(TSM) for each voxel. We observed early hemodynamic changes in high grade glioma and found significant difference in the mean TSM ratio between Glioblastoma(GBM) and low grade tumors. TSM also appeared similar to rCBV perfusion maps.

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