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Abstract #0246

In vivo 7T Quantitative Susceptibility Mapping of Cortical Lesions in Multiple Sclerosis

Wei Bian1, Eric Tranvinh1, Thomas Tourdias2, May Han3, Tian Liu4, Yi Wang4, Brian Rutt1, and Michael Zeineh1

1Department of Radiology, Stanford University, Stanford, CA, United States, 2Service de NeuroImagerie Diagnostique et Thérapeutique, CHU de Bordeaux, Bordeaux, France, 3Department of Neurology, Stanford University, Stanford, CA, United States, 4Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States

Magnetic susceptibility measured with quantitative susceptibility mapping (QSM) has been proposed as a biomarker for inflammation in multiple sclerosis (MS) white matter (WM) lesions. However, a detailed in vivo characterization of cortical lesions has not been performed. In this study, the susceptibility in both cortical and WM lesions relative to adjacent normal-appearing parenchyma was measured and compared for 14 MS patients using QSM at 7T. Our results showed that relative susceptibility was negative for cortical lesions but positive for WM lesions. The opposite pattern of relative susceptibility suggests that iron loss dominates the susceptibility contrast in cortical lesions.

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