Abstract #0262

Extracting Quantitative Information From MRI Bound- and Pore-Water Maps of Cortical Bone

Mary Kate Manhard¹, Sasidhar Uppuganti², Mathilde C Granke², Daniel F Gochberg³, Jeffry S Nyman², and Mark D Does¹

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Department of Orthopaedics & Rehabilitation, Vanderbilt University, Nashville, TN, United States, ³Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

Bound and pore water concentration measures of cortical bone found from MRI have been shown to correlate with material properties of bone, but the ideal way to analyze and draw information from 3D quantitative maps remains unclear. Material properties of cadaver radii found from a 3-point bend test were correlated with characteristics of the distribution of bound and pore water concentrations (e.g. mean, skewness) in ROIs found from different segmentations. Results highlighted the importance of segmentation method as well as quantitative measures drawn from the maps.

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