Abstract #0269

Quantitative MRI of Renal Function in a Mouse Model of Unilateral Ureteral Obstruction

Haiying Tang¹, Matthew Fronheiser¹, Guoqiang Zhang², Adrienne Pena¹, Daniel Kukral¹, Cindy Cai², Rachel Zebo², Jeff L L Zhang³, Bradley Zinker², Anthony Azzara², Patrick Chow¹, Feng Luo⁴, and Wendy Hayes¹

¹Bristol Myers Squibb, Princeton, NJ, United States, ²Bristol Myers Squibb, Hopewell, NJ, United States, ³Radiology, University of Utah, Salt Lake City, UT, United States, ⁴Bristol Myers Squibb, Wallingford, CT, United States

Recent advances in magnetic resonance imaging (MRI) allow the development of non-invasive and quantitative tools to assess renal function. DCE-MRI using low dose Gd-based contrast has been established as a reliable technique for measuring glomerular filtration rate (GFR) in individual kidneys. Other promising markers for renal function include R2* measured with BOLD MRI, and the longitudinal relaxation time T1. Unilateral ureteral obstruction (UUO) has been developed in rodents as a model of renal fibrosis. The purpose of the study is to evaluate the various MRI techniques in assessing kidney tissue properties and renal function in the UUO mouse model.

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