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Abstract #0269

Quantitative MRI of Renal Function in a Mouse Model of Unilateral Ureteral Obstruction

Haiying Tang1, Matthew Fronheiser1, Guoqiang Zhang2, Adrienne Pena1, Daniel Kukral1, Cindy Cai2, Rachel Zebo2, Jeff L L Zhang3, Bradley Zinker2, Anthony Azzara2, Patrick Chow1, Feng Luo4, and Wendy Hayes1

1Bristol Myers Squibb, Princeton, NJ, United States, 2Bristol Myers Squibb, Hopewell, NJ, United States, 3Radiology, University of Utah, Salt Lake City, UT, United States, 4Bristol Myers Squibb, Wallingford, CT, United States

Recent advances in magnetic resonance imaging (MRI) allow the development of non-invasive and quantitative tools to assess renal function. DCE-MRI using low dose Gd-based contrast has been established as a reliable technique for measuring glomerular filtration rate (GFR) in individual kidneys. Other promising markers for renal function include R2* measured with BOLD MRI, and the longitudinal relaxation time T1. Unilateral ureteral obstruction (UUO) has been developed in rodents as a model of renal fibrosis. The purpose of the study is to evaluate the various MRI techniques in assessing kidney tissue properties and renal function in the UUO mouse model.

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