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Abstract #0277

Neurite Orientation Dispersion and Density Imaging (NODDI) in Young Onset Alzheimer's Disease and Its Syndromic Variants

Jiaying Zhang1, Catherine F Slattery2, Ross W Paterson2, Alexander JM Foulkes2, Laura Mancini2, David L Thomas2, Marc Modat1, Nicolas Toussaint2, David M Cash2, John S Thornton2, Daniel C Alexander1, Sebastien Ourselin1, Nick C Fox2, Jonathan M Schott2, and Hui Zhang1

1Department of Computer Science and Centre for medical image computing, University College London, London, United Kingdom, 2Department of Neurodegenerative disease, Institute of Neurology, University College London, London, United Kingdom

Alzheimer's disease (AD) is now increasingly considered as a disorder of brain networks. Therefore, it is important to quantify the integrity of white matter (WM) connections in AD populations. Previous DTI studies have shown WM breakdown in patients with young onset AD (YOAD), but DTI parameters are not specific to any tissue property. Here we investigated WM changes using NODDI and DTI in YOAD patients using TBSS and explored whether unique patterns of WM changes exist in YOAD subtypes. We found NODDI was more sensitive than DTI and demonstrated different profiles of WM damage in YOAD syndromic subgroups.

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