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Abstract #0286

A constrained slice-dependent background suppression scheme for simultaneous multi-slice pseudo-continuous arterial spin labeling

Xingfeng Shao1, Yi Wang1, and Danny J.J. Wang1

1Laboratory of FMRI Technology (LOFT), Department of Neurology, University of California Los Angeles, Los Angeles, CA, United States

Compared to standard two-dimensional (2D) arterial spin labeling (ASL), simultaneous multi-slice (SMS) ASL imaging techniques can reduce T1 relaxation effect of the label; improve spatial coverage and resolution. However, existing 2D SMS ASL techniques are sub-optimal for the background suppression (BS) technique since multiple SMS excitations are required. In this study, we propose a novel constrained slice-dependent BS scheme for 2D multi-slice pseudo-continuous ASL (pCASL) with SMS-EPI acquisition, to suppress background signal across a wide range of T1s. In vivo experiment showed that the BS scheme can increase temporal SNR of perfusion images 1.5-2 folds.

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