Abstract #0288

Radiogenomic analysis of glioblastoma using protein-based amide proton transfer (APT) imaging and message RNA expression: A novel correlation in molecular imaging and gene characteristics

Shanshan Jiang¹, Xianlong Wang¹, Hao Yu¹, Jiandong Xi¹, Jingwen Wu¹, Lisong Liang¹, Shilong Lu¹, Tianyu Zou¹, Jinyuan Zhou², and Zhibo Wen¹

¹Department of Radiology, Southern Medical University Zhujiang Hospital, Guangzhou, China, People's Republic of, ²Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

The correlation between endogenous protein-based APT-weighted (APTw) imaging and gene expression in glioblastoma (GBM) was investigated. 16 patients with newly diagnosed GBM were studied. APTw/FLAIR hyperintensity area ratio (AFR), and APTw hyperintensity/gadolinium contrast-enhanced T1w enhancement area ratio (ATR) were calculated. Interoperative paired tumor and adjacent normal tissues were sampled for genomic analysis. BRCA1 and CDK4 were significantly downregulated in the high AFR group (adjusted P= 0.000953 and 0.025187), and SLAMF9 and MIA were significantly downregulated in the high ATR group (adjusted P= 1.08E-11 and 0.00997). APT imaging has great potential for unveiling some special genomic changes in GBM.

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