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Abstract #0290

Low Apparent Diffusion Coefficient Values Correlate with Enhancing Mitosis and Cell Proliferation Expression in glioblastoma using Locus-Specific Radiogenomic Map

Cheng-Yu Chen1,2,3, Fei-Ting Hsu1, Hua-Shan Liu1,4, Ping-Huei Tsai1,3, Chia-Feng Lu2,3,5, Yu-Chieh Kao2,3, Li-Chun Hsieh1, and Pen-Yuan Liao1

1Department of Medical Image, Taipei Medical University Hospital, Taipei, Taiwan, 2Translational Imaging Research Center, College of Medicine, Taipei Medical University, Taipei, Taiwan, 3Department of Radiology, School of Medicine, Taipei Medical University, Taipei, Taiwan, 4Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan, 5Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan

A new approach to unravel the genomic expression of glioblastoma by advanced MR imaging technique has recently been introduced to improve the prognostic and predictive efficacies of neuroimaging. This imaging method is potentially a valuable tool to link individual differences in the human genome to structure, function and physiology into brain disease, a method referred to as radiogenomics. In this study, we established locus specific radiogenomic map based on MR imaging and Microarray RNA analysis. Our results revealed that apparent diffusion coefficient (ADC) differences were correlated with several biological processes change, including cell proliferation, T cell immunity, immune response, and mitosis. The identification of tumor genotypes by imaging phenotypes will open a new era of therapeutic strategy in high grade gliomas.

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