Iris Yuwen Zhou1, Jinsuh Kim2, Takahiro Igarashi1, Lingyi Wen1, and Phillip Zhe Sun1
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 2Department of Radiology, University of Illusions at Chicago, Chicago, IL, United States
To
resolve metabolites at different chemical shift offsets, complete Z-spectrum is
conventionally obtained by varying saturation offset from scan to scan, which
is time consuming and not suitable for studying dynamic changes. To overcome
this, we innovatively combined superfast Z spectroscopy with chemical shift
imaging (CSI) and developed Superfast Chemical exchange saturation transfer
(CEST) Spectral Imaging (SCSI). It provides fast Z-spectral CEST information
with spatial resolution. While conventional CSI measures dilute metabolites,
the proposed SCSI exploits CEST mechanism to investigate the interaction
between metabolites/contrast agents and tissue water, providing sensitivity
enhanced measurements of metabolites and pH information.
