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Abstract #0304

Implementing single-shot quantitative CEST/T1ρ measurements using bSSFPX

Shu Zhang1, Robert E Lenkinski1,2, and Elena Vinogradov1,2

1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

Recently properties of bSSFP were explored to detect exchange processes (bSSFPX), similar to CEST or off-resonance T experiments. We expand the study and implement a transient bSSFPX experiment that acquires bSSFP spectra continuously as the effective saturation time increases, allowing observation of the approach of magnetization to the steady state in a single shot. The magnetization dynamic is governed by the effective field and relaxation times parallel or perpendicular to it. Work is in progress to derive an exact quantification model. The method leads to fast acquisition of time-dependent data and may speed up QUEST-like quantification of the exchange processes.

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