Abstract #0306

In vivo quantitative Magnetisation Transfer in the cervical spinal cord using reduced Field-of-View imaging: a feasibility study

Marco Battiston¹, Francesco Grussu¹, James E. M. Fairney^2,3, Ferran Prados^1,4, Sebastien Ourselin⁴, Mara Cercignani⁵, Claudia Angela Michela Gandini Wheeler-Kingshott^1,6, and Rebecca S Samson¹

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, United Kingdom, ²UCL Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ³Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, United Kingdom, ⁴Translational Imaging Group, Centre for Medical Image Computing, UCL Department Medical Physics and Bioengineering, University College London, London, United Kingdom, ⁵CISC, Brighton & Sussex Medical School, Brighton, United Kingdom, ⁶Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy

Quantitative Magnetization Transfer (qMT) Imaging techniques offer the possibility to estimate tissue macromolecular fraction, which has been shown to be specific for myelin in the brain and spinal cord. To date, applications of qMT in the spinal cord have been hampered by prohibitive protocol duration. We propose a novel approach for qMT in the spinal cord based on the combination of off-resonance saturation and small field-of-view imaging, with the potential of reducing the scan time needed to perform qMT in the spinal cord.

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