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Abstract #0309

Beat-to-beat blood pressure fluctuations are present in time-frequency dynamics of resting-state fMRI

Joseph R Whittaker1, Molly G Bright1,2, Ian D Driver1, and Kevin Murphy1

1CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

A pilot study of fMRI time-frequency dynamics, characterized using a maximal overlap discrete wavelet transform, demonstrates matched frequency correlations with beat-to-beat mean arterial blood pressure fluctuations. Voxel-wise correlations between fMRI and blood pressure wavelet coefficients, on a frequency scale centred at 0.1Hz, reveal distributed and structured spatial variance across the brain. We demonstrate that functional connectivity methods that include time-frequency representations of fMRI data are likely very sensitive to these blood pressure fluctuations.

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