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Abstract #0321

Vortex-ring mixing as a measure of diastolic function of the human heart: phantom validation and initial observations in healthy volunteers and patients with heart failure

Johannes Töger1,2, Mikael Kanski1, Per M Arvidsson1, Marcus Carlsson1, Sándor J Kovács3, Rasmus Borgquist4, Johan Revstedt5, Gustaf Söderlind2, Håkan Arheden1, and Einar Heiberg1,2,6

1Department of Clinical Physiology, Lund University Hospital, Lund University, Lund, Sweden, 2Department of Numerical Analysis, Centre for Mathematical Sciences, Lund University, Lund, Sweden, 3Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, United States, 4Department of Arrhythmias, Lund University Hospital, Lund University, Lund, Sweden, 5Department of Energy Sciences, Lund University, Faculty of Engineering, Lund, Sweden, 6Department of Biomedical Engineering, Lund University, Faculty of Engineering, Lund, Sweden

Diastolic dysfunction of the left ventricle (LV) of the heart is a severe condition associated with poor prognosis. However, objective and reproducible assessment of diastolic function remains a challenge. We propose a new method using 4D flow MR by quantification of blood mixing within the LV diastolic vortex-ring. Phantom validation showed fair agreement between 4D flow MR and planar laser-induced fluorescence (PLIF). Quantitative vortex-ring mixing differs between healthy controls and patients with heart failure, which demonstrates its potential as a marker of diastolic dysfunction.

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