Abstract #0321

Vortex-ring mixing as a measure of diastolic function of the human heart: phantom validation and initial observations in healthy volunteers and patients with heart failure

Johannes Töger^1,2, Mikael Kanski¹, Per M Arvidsson¹, Marcus Carlsson¹, Sándor J Kovács³, Rasmus Borgquist⁴, Johan Revstedt⁵, Gustaf Söderlind², Håkan Arheden¹, and Einar Heiberg^1,2,6

¹Department of Clinical Physiology, Lund University Hospital, Lund University, Lund, Sweden, ²Department of Numerical Analysis, Centre for Mathematical Sciences, Lund University, Lund, Sweden, ³Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, United States, ⁴Department of Arrhythmias, Lund University Hospital, Lund University, Lund, Sweden, ⁵Department of Energy Sciences, Lund University, Faculty of Engineering, Lund, Sweden, ⁶Department of Biomedical Engineering, Lund University, Faculty of Engineering, Lund, Sweden

Diastolic dysfunction of the left ventricle (LV) of the heart is a severe condition associated with poor prognosis. However, objective and reproducible assessment of diastolic function remains a challenge. We propose a new method using 4D flow MR by quantification of blood mixing within the LV diastolic vortex-ring. Phantom validation showed fair agreement between 4D flow MR and planar laser-induced fluorescence (PLIF). Quantitative vortex-ring mixing differs between healthy controls and patients with heart failure, which demonstrates its potential as a marker of diastolic dysfunction.

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