Abstract #0351

Ultimate hyperthermia: Computation of the best achievable radio-frequency hyperthermia treatments in non-uniform body models

Bastien Guerin^1,2, Jorge F. Villena³, Athanasios G. Polimeridis⁴, Elfar Adalsteinsson^5,6,7, Luca Daniel⁵, Jacob K. White⁵, Bruce R. Rosen^1,2,6, and Lawrence L. Wald^1,2,6

¹A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Cadence Design Systems, Feldkirchen, Germany, ⁴Skolkovo Institute of Science and Technology, Moscow, Russian Federation, ⁵Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁶Harvard-MIT Division of Health Sciences Technology, Cambridge, MA, United States, ⁷Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States

We propose a framework for the computation of the ultimate hyperthermia, which is the best possible hyperthermia treatment for a given frequency and non-uniform body model achievable by any multi-channel hyperthermia coil. We compute the ultimate hyperthermia treatment of two shallow (close to skull) and deep (close to ventricle) brain tumors in the realistic “Duke” body model and for treatment frequencies ranging from 64 MHz to 600 MHz. We characterize the convergence to the ultimate SAR pattern as well as temperature increase associated with the ultimate SAR distribution in the presence of non-uniform perfusion effects.

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