Abstract #0369

Detection of Alterations in Intramyocellular Lipid and Creatine Diffusivities during Muscle Ischemia by Diffusion Weighted MRS

Anna M. WANG^1,2 and Ed X. Wu^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, People's Republic of, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China, People's Republic of

We measured the apparent diffusion coefficients (ADCs), as well as the relative concentrations of both intramyocellular lipid (IMCL) and creatine in the rat muscle ischemia model. Comparing with the metabolite concentration changes, the IMCL and creatine ADCs had largely increased during muscle ischemia and the IMCL ADC increase was more drastic than creatine. The IMCL ADC, measured by diffusion weighted MRS, had shown the potential to probe the alterations in lipid droplet size and lipid metabolism in skeletal muscles.

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