Gilbert Hangel1, Bernhard Strasser2, Michal Považan2, Lukas Hingerl1, Marek Chmelík2, Stephan Gruber2, Siegfried Trattnig2,3, and Wolfgang Bogner2
1MR Centre of Excellence, Medical University of Vienna, Vienna, Austria, 2MRCE, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria
Increasing the resolution of MRSI is desirable to delineate
small structures and pathologic deviations such as Multiple Sclerosis lesions and
increase local B0-homogeneity per voxel. We show that using an
FID-MRSI sequence with short TR and L2-regularisation for lipid contamination
removal, the major brain metabolites can be mapped with a 128x128 matrix over a
whole brain slice with unprecedented detail, with a nominal voxel volume of
1.7×1.7×8 mm³. The additional application of parallel imaging allows reducing
measurement times enough for potential clinical applications.
