Abstract #0387

Metabolic mapping of the brain using ultra-high resolution MRSI at 7 T

Gilbert Hangel¹, Bernhard Strasser², Michal Považan², Lukas Hingerl¹, Marek Chmelík², Stephan Gruber², Siegfried Trattnig^2,3, and Wolfgang Bogner²

¹MR Centre of Excellence, Medical University of Vienna, Vienna, Austria, ²MRCE, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

Increasing the resolution of MRSI is desirable to delineate small structures and pathologic deviations such as Multiple Sclerosis lesions and increase local B0-homogeneity per voxel. We show that using an FID-MRSI sequence with short TR and L2-regularisation for lipid contamination removal, the major brain metabolites can be mapped with a 128x128 matrix over a whole brain slice with unprecedented detail, with a nominal voxel volume of 1.7×1.7×8 mm³. The additional application of parallel imaging allows reducing measurement times enough for potential clinical applications.

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