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Abstract #0416

Optimized Cardiac CEST MRI for Assessment of Metabolic Activity in the Heart

Zhengwei Zhou1,2, Yuhua Chen3, Yibin Xie1, Christopher Nguyen1, Mu Zeng4, James Dawkins5, Zhanming Fan4, Eduardo Marbán5, and Debiao Li1,2,5

1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Department of Computer and Information Science, University of Pennsylvania, Philadelphia, PA, United States, 4Department of Radiology, Anzhen Hospital, Capital Medical University, Beijing, China, People's Republic of, 5Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States

In this work, we developed an optimized cardiac CEST method to detect myocardial metabolic change with significantly reduced scan time. Our initial results in porcine model with chronic myocardial infarction show that scar region has lower metabolic activity compared to healthy myocardium, using LGE as reference. This study also shows the feasibility of cardiac CEST imaging in a patient, for the first time.

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