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Abstract #0424

Impact of calibration method on the reproducibility of CBF mapping using multiple post-labeling-delay PASL

Joana Pinto1, Pedro Vilela2, Michael A. Chappell3, and Patrícia Figueiredo1

1ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico – Universidade de Lisboa, Lisbon, Portugal, 2Imaging Department, Hospital da Luz, Lisbon, Portugal, 3Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom

Absolute CBF quantification using ASL requires the normalization of the control-label difference images by the equilibrium magnetization, M0. A voxelwise calibration method is currently recommended for single post-labelling-delay (PLD) PCASL. However, the impact of using an M0t map obtained directly from the ASL data, with no need for an extra scan, by fitting a saturation-recovery curve to the control image time-series in multiple-PLD PASL remains to be investigated. Here, we show that, using this type of acquisition, voxelwise calibration significantly reduced inter- and intra-subject variability in gray matter CBF measurements relative to methods based on a reference tissue.

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