Abstract #0424

Impact of calibration method on the reproducibility of CBF mapping using multiple post-labeling-delay PASL

Joana Pinto¹, Pedro Vilela², Michael A. Chappell³, and Patrícia Figueiredo¹

¹ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico – Universidade de Lisboa, Lisbon, Portugal, ²Imaging Department, Hospital da Luz, Lisbon, Portugal, ³Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom

Absolute CBF quantification using ASL requires the normalization of the control-label difference images by the equilibrium magnetization, M0. A voxelwise calibration method is currently recommended for single post-labelling-delay (PLD) PCASL. However, the impact of using an M_0t map obtained directly from the ASL data, with no need for an extra scan, by fitting a saturation-recovery curve to the control image time-series in multiple-PLD PASL remains to be investigated. Here, we show that, using this type of acquisition, voxelwise calibration significantly reduced inter- and intra-subject variability in gray matter CBF measurements relative to methods based on a reference tissue.

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