Abstract #0452

MRI assessment of Changes in Tumor Oxygenation post Hypoxia-targeted Therapy

Shubhangi Agarwal¹, Troy Kozlowski¹, Rohini Vidya Shankar¹, Landon J. Inge², and Vikram D. Kodibagkar¹

¹SBHSE, Arizona State University, Tempe, AZ, United States, ²St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States

Solid tumors have hypoxic foci that be targeted using hypoxia activated/targeting drugs. Utilizing quantitative MR oximetry techniques such as the PISTOL (Proton Imaging of Siloxanes to map Tissue Oxygenation Levels) technique could allow for patient stratification for personalized therapy. This study uses the PISTOL technique to evaluate how the hypoxia activated drug TPZ (Tirapazamine) depends on and affects the oxygenation and edema fraction of epidermoid carcinoma (A431) and non-small cell lung cancer (H1975). Surprisingly, TPZ was more effective on the H1975 tumors than A431, in spite of higher pre-treatment pO2 levels, potentially due to perfusion-related differences in tumor drug delivery.

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