Abstract #0454

How Accurately and Precisely Are we Measuring Coronary Endothelial Function with Radial MRI?

Jerome Yerly^1,2, Danilo Gubian³, Jean-Francois Knebel^2,4, Thomas Robin⁵, Giulia Ginami¹, and Matthias Stuber^1,2

¹CardioVascular Magnetic Resonance (CVMR) research center, Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ²Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, ³University Hospital (CHUV), Lausanne, Switzerland, ⁴Laboratory for Investigative Neurophysiology (The LINE), Departments of Radiology and Clinical Neurosciences, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ⁵Transport and Mobility Laboratory (TRANSP-OR), Swiss Federal Institute of Technology of Lausanne (EPFL), Lausanne, Switzerland

MRI with isometric handgrip exercise was recently proposed to non-invasively assess coronary endothelial function. However, the sensitivity of this technique has not yet been fully investigated. To address this need, we have designed a phantom that simulates a physiological range of coronary cross-sectional areas. Radial cine MR images with different spatial resolutions were acquired under moving conditions. Cross-sectional areas were automatically measured and compared to the known nominal values. Statistical analysis suggests that MRI is capable of distinguishing area changes in the order of 0.2-0.3mm², which correspond to a percentage coronary area change of 3-4% for a 3mm baseline diameter.

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