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Abstract #0454

How Accurately and Precisely Are we Measuring Coronary Endothelial Function with Radial MRI?

Jerome Yerly1,2, Danilo Gubian3, Jean-Francois Knebel2,4, Thomas Robin5, Giulia Ginami1, and Matthias Stuber1,2

1CardioVascular Magnetic Resonance (CVMR) research center, Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, 3University Hospital (CHUV), Lausanne, Switzerland, 4Laboratory for Investigative Neurophysiology (The LINE), Departments of Radiology and Clinical Neurosciences, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 5Transport and Mobility Laboratory (TRANSP-OR), Swiss Federal Institute of Technology of Lausanne (EPFL), Lausanne, Switzerland

MRI with isometric handgrip exercise was recently proposed to non-invasively assess coronary endothelial function. However, the sensitivity of this technique has not yet been fully investigated. To address this need, we have designed a phantom that simulates a physiological range of coronary cross-sectional areas. Radial cine MR images with different spatial resolutions were acquired under moving conditions. Cross-sectional areas were automatically measured and compared to the known nominal values. Statistical analysis suggests that MRI is capable of distinguishing area changes in the order of 0.2-0.3mm2, which correspond to a percentage coronary area change of 3-4% for a 3mm baseline diameter.

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