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Abstract #0457

Preliminary Results: Cardiac Cine “Watermark” MRI provides both Anatomical Function via Magnitude Cine and 2D Myocardial Strain via Spatially Modulated Phase

Ronald J Beyers1, Davis M Vigneault2, Dean Schwartz3, Nouha Salibi1,4, David A Bluemke2, and Thomas Denney1

1MRI Research Center, Auburn University, Auburn University, AL, United States, 2Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States, 3Anatomy, Physiology and Pharmacology, Auburn University, Auburn University, AL, United States, 4MR R&D, Siemens Healthcare, Malvern, PA, United States

We developed a Cine Watermark (CWM) cine sequence that produces normal cine magnitude images, plus a grid pattern of tags added only in the phase for quantitative cine strain, while requiring no extra operator effort. Using spatial cosine modulation combined with k-space sum/differencing produced separate normal magnitude cine and unique phase-only grid-tags for strain calculation. In vivo rat and human scans demonstrated good magnitude cine and phase-only quantified displacement. Calculated by Farneback optical flow algorithm, the peak principle strain, averaged around the LV for rat = -16.5±2.4 % and human = -17.8±6.2 % (mean±StdDev).

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