Abstract #0488

Line scanning BOLD fMRI upon optogenetic stimulation

Franziska Albers¹, Florian Schmid¹, Lydia Wachsmuth¹, and Cornelius Faber¹

¹Department of Clinical Radiology, University of Münster, Münster, Germany

With the line scanning technique BOLD responses can be recorded with 50 ms temporal resolution. Here line scanning fMRI was combined with optogenetic stimulation of excitatory neurons in rat somatosensory cortex. The light for optogenetic stimulation was delivered by an optical fiber implanted in the brain. It was possible to compare BOLD responses upon optogenetic and sensory stimulation with high temporal resolution and shorter times to reach half maximum were found for optogenetic stimulation. Furthermore the spatial resolution offered the possibility to observe cortical layer-specific BOLD signals.

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