Abstract #0526

Magnetic Resonance Imaging of the Pancreas in a Transgenic Mouse Model of Pancreatic Carcinogenesis

Conny F. Waschkies^1,2, Theresia F. Reding¹, Gitta Maria Seleznik¹, Udo Ungethuem¹, and Rolf Graf¹

¹Division of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland, ²Institute for Biomedical Engineering, ETH and University Zurich, Zurich, Switzerland

Few preclinical studies rely on MRI to monitor pancreatic tissue changes in commensurate animal models, mostly due to inherently low conspicuity of the rodent pancreas. Pancreatic inflammation is a risk factor for pancreatic ductal adenocarcinoma development, and its initiation is linked to activating mutations in KRAS oncogene, known as the KPC mouse model. In the present study we demonstrate the potential of preclinical MRI to visualize the murine pancreas and its changes associated with cellular transformations in this mouse model of pancreatic carcinogenesis.

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