Abstract #0530

Prediction of response by DCE-MRI and DW-MRI for intrahepatic cholangiocarcinomas treated with locoregional and systemic chemotherapy: a preliminary analysis

Kristen L Zakian¹, Richard K Do², Taryn Boucher², Mithat Gonen³, Andrea Cercek⁴, William R Jarnagin⁵, and Nancy Kemeny⁴

¹Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ²Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ³Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ⁴Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ⁵Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, United States

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignancy and has few treatment options. A previous study suggested that MRI may help identify patients likely to benefit from hepatic arterial infusion pump therapy with floxuridine (HAI-FUDR). The purpose of this prospective study was to investigate the ability of pre-treatment and early-in-treatment DCE and DW-MRI to predict ICC response to combined HAI-FUDR and systemic chemotherapy given in a Phase 2 clinical trial. Our preliminary analysis suggests that DW-MRI may predict response of unresectable ICC using data acquired at baseline or at 1 month after treatment start.

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