Abstract #0552

MR Guided Focused Ultrasound Thalamotomy for Essential Tremor - Maryland Experience

Rao P Gullapalli¹, Jiachen Zhuo¹, Dheeraj Gandhi¹, Charlene Aldrich², Erma Owens¹, John Hebel¹, Paul Fishman³, Howard Eisenberg², and Elias Melhem¹

¹Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ²Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States, ³Neurology, University of Maryland School of Medicine, Baltimore, MD, United States

In the context of the remarkable reduction in tremors and improvement in quality of life at one year following MRgFUS thalamotomy procedure to treat Essential Tremors in a recently concluded multi-center trial, we examined pre- and post-imaging data including an assessment of the accuracy of MRgFUS targeting of the VIM nuclei and lesion evolution over 12 months. Lesions generated by this procedure were accurately placed, and matched well with the known location of VIM nucleus based on anatomical atlases. The lesions appear to regress in size over a 12 month period but the therapeutic effect is maintained.

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