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Abstract #0566

Segmentation of the fetal brain cortical plate using diffusion-weighted imaging cues

Rosita Shishegar1,2, Shreya Rana3, Mary Tolcos3, David W. Walker3, and Leigh A. Johnston1,4

1Dept. Electrical & Electronic Engineering, University of Melbourne, Melbourne, Australia, 2NICTA Victoria Research Laboratory, Melbourne, Australia, 3The Ritchie Centre, Hudson Institute of Medical Research, Monash University, Melbourne, Australia, 4Florey Institute of Neuroscience and Mental Health, Melbourne, Australia

Segmentation of the developing cortical plate from MRI data of the fetal brain is highly challenging due to partial volume effects, low contrast and heterogeneous maturation caused by ongoing myelination processes. We present a new atlas-free method for segmenting the boundary between the cortical plate and subplate in fetal brains, by exploiting diffusion-weighted imaging cues. The accuracy of the segmentation algorithm is demonstrated by application to fetal sheep brain MRI data.

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