Abstract #0574

Reproducibility of Brown Adipose Tissue Assessment in Healthy Volunteers based on Time-Resolved Dixon MRI

Vanessa Stahl¹, Armin M. Nagel^1,2, Martin T. Freitag³, Ralf O. Floca⁴, Moritz C. Berger ¹, Reiner Umathum¹, Mauricio Berriel Diaz⁵, Stephan Herzig⁵, Marc-André Weber⁶, Antonia Dimitrakopoulou-Strauss⁷, Peter Bachert¹, Mark E. Ladd¹, and Florian Maier¹

¹Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, ²Department of Diagnostic and Interventional Radiology, University Medical Center Ulm, Ulm, Germany, ³Department of Radiology, German Cancer Research Center, Heidelberg, Germany, ⁴Medical and Biological Informatics, German Cancer Research Center, Heidelberg, Germany, ⁵Institute for Diabetes and Cancer, Helmholtz Zentrum München German Research Center for Environmental Health, München, Germany, ⁶Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany, ⁷Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany

Brown adipose tissue (BAT) is subject of ongoing metabolic and obesity research having the ability to dissipate energy through non-shivering thermogenesis. This study was performed to evaluate reproducibility of recently shown time-resolved fat-fraction (FF) MR measurements during cold exposure for BAT assessment. BAT mass and activity were compared to the previous results assessed in the interscapular BAT depots. Potential BAT depots were observed at reproducible anatomic positions, showing a reproducible FF evolution with a mean FF decrease of (-2.31±1.05)%/h during cold-activation.

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