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Abstract #0574

Reproducibility of Brown Adipose Tissue Assessment in Healthy Volunteers based on Time-Resolved Dixon MRI

Vanessa Stahl1, Armin M. Nagel1,2, Martin T. Freitag3, Ralf O. Floca4, Moritz C. Berger 1, Reiner Umathum1, Mauricio Berriel Diaz5, Stephan Herzig5, Marc-André Weber6, Antonia Dimitrakopoulou-Strauss7, Peter Bachert1, Mark E. Ladd1, and Florian Maier1

1Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 2Department of Diagnostic and Interventional Radiology, University Medical Center Ulm, Ulm, Germany, 3Department of Radiology, German Cancer Research Center, Heidelberg, Germany, 4Medical and Biological Informatics, German Cancer Research Center, Heidelberg, Germany, 5Institute for Diabetes and Cancer, Helmholtz Zentrum München German Research Center for Environmental Health, München, Germany, 6Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany, 7Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany

Brown adipose tissue (BAT) is subject of ongoing metabolic and obesity research having the ability to dissipate energy through non-shivering thermogenesis. This study was performed to evaluate reproducibility of recently shown time-resolved fat-fraction (FF) MR measurements during cold exposure for BAT assessment. BAT mass and activity were compared to the previous results assessed in the interscapular BAT depots. Potential BAT depots were observed at reproducible anatomic positions, showing a reproducible FF evolution with a mean FF decrease of (-2.31±1.05)%/h during cold-activation.

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