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Abstract #0578

Detection of Aggressive Prostate Cancer Using Extradomain-B Fibronectin Targeted MRI Contrast Agent

Zheng Han1, Yajuan Li1, and Zheng-Rong Lu1

1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Prostate cancer (PCa) is the second most lethal cancer in American men with a high incidence rate. Current method of PCa screening is not specific to aggressive cancer type, which results in overtreatment with serious adverse effects. We developed a MRI contrast agent, ZD2-Gd(HP-DO3A), that targets to overexpressed extradomain-B in aggressive PCa. Our result showed an increased sensitivity for MRI detection of aggressive PCa using ZD2-Gd(HP-DO3A), compared with the clinical control agent ProHance®. This contrast agent can potentially facilitate accurate risk stratification and clinical management of PCa.

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