Abstract #0598

Ex-vivo Quantitative Imaging and Qualitative Plaque Type Classification of Intracranial Atherosclerotic Plaque using High Resolution MRI

Yuanliang Jiang¹, Chengcheng Zhu², Andrew J Degnan³, Wenjia Peng¹, Luguang Chen¹, Xinrui Wang¹, Qi Liu¹, Yang Wang⁴, Zhenzhen Xiang⁴, Zhongzhao Teng⁵, David Saloner², and Jianping Lu¹

¹Radiology, Changhai Hospital, Shanghai, China, People's Republic of, ²Radiology, University of California, San Francisco, San Francisco, CA, United States, ³Radilogy, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Pathology, Changhai Hospital, Shanghai, China, People's Republic of, ⁵Radiology, University of Cambridge, Cambridge, United Kingdom

The first ex vivo measurement of T1, T2, and T2* relaxation times of intracranial plaque components at 3T is reported. The ability of multi-contrast MRI to characterize plaque type was evaluated with histological validation. Plaque components could be differentiated based on relaxation times. Specifically, lipid core had significantly lower T2 values than fibrous cap. MRI and histology correlation was consistent across specimens and locations, and MRI showed a high sensitivity and specificity for identifying plaque features previously associated with high-risk. Therefore, MRI has the potential to characterize intracranial plaque composition and improve patient risk stratification.

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