Meeting Banner
Abstract #0598

Ex-vivo Quantitative Imaging and Qualitative Plaque Type Classification of Intracranial Atherosclerotic Plaque using High Resolution MRI

Yuanliang Jiang1, Chengcheng Zhu2, Andrew J Degnan3, Wenjia Peng1, Luguang Chen1, Xinrui Wang1, Qi Liu1, Yang Wang4, Zhenzhen Xiang4, Zhongzhao Teng5, David Saloner2, and Jianping Lu1

1Radiology, Changhai Hospital, Shanghai, China, People's Republic of, 2Radiology, University of California, San Francisco, San Francisco, CA, United States, 3Radilogy, University of Pittsburgh, Pittsburgh, PA, United States, 4Pathology, Changhai Hospital, Shanghai, China, People's Republic of, 5Radiology, University of Cambridge, Cambridge, United Kingdom

The first ex vivo measurement of T1, T2, and T2* relaxation times of intracranial plaque components at 3T is reported. The ability of multi-contrast MRI to characterize plaque type was evaluated with histological validation. Plaque components could be differentiated based on relaxation times. Specifically, lipid core had significantly lower T2 values than fibrous cap. MRI and histology correlation was consistent across specimens and locations, and MRI showed a high sensitivity and specificity for identifying plaque features previously associated with high-risk. Therefore, MRI has the potential to characterize intracranial plaque composition and improve patient risk stratification.

This abstract and the presentation materials are available to members only; a login is required.

Join Here