Abstract #0624

Potential Improvement in Apparent Diffusion Coefficient (ADC) Measurement by Respiratory Correlated Four Dimensional Diffusion-Weighted MRI (4D-DWI): Initial Investigation on Digital Phantoms and Human Subjects

Yilin Liu¹, Fang-Fang Yin², Brian Gary Czito², Mustafa R. Bashir ³, Manisha Palta ², Xiaodong Zhong ⁴, Brian M. Dale ⁵, and Jing Cai²

¹Medical Physics Graduate Program, Duke University Medical Center, Durham, NC, United States, ²Radiation Oncology, Duke University Medical Center, Durham, NC, United States, ³Department of Radiology, Center for Advanced Magnetic Resonance Development, Duke University Medical Center, Durham, NC, United States, ⁴MR R&D Collaborations, Siemens Healthcare, Atlanta, GA, United States, ⁵MR R&D Collaborations, Siemens Healthcare, Cary, NC, United States

Diffusion-weighted imaging (DWI) has been shown to have superior tumor-to-tissue contrast for cancer detection in abdominal region. However, the respiratory motion may induce severe imaging errors or artifacts for DWI images. This study aims at developing and evaluating a respiratory correlated 4D-DWI technique using a retrospective sorting method for imaging respiratory motion on human subjects. Comparing to free breathing DWI, 4D-DWI can lead to more accurate measurement of ADC. This has a great potential to improve the visualization and delineation of cancer tumors for radiotherapy.

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