Meeting Banner
Abstract #0624

Potential Improvement in Apparent Diffusion Coefficient (ADC) Measurement by Respiratory Correlated Four Dimensional Diffusion-Weighted MRI (4D-DWI): Initial Investigation on Digital Phantoms and Human Subjects

Yilin Liu1, Fang-Fang Yin2, Brian Gary Czito2, Mustafa R. Bashir 3, Manisha Palta 2, Xiaodong Zhong 4, Brian M. Dale 5, and Jing Cai2

1Medical Physics Graduate Program, Duke University Medical Center, Durham, NC, United States, 2Radiation Oncology, Duke University Medical Center, Durham, NC, United States, 3Department of Radiology, Center for Advanced Magnetic Resonance Development, Duke University Medical Center, Durham, NC, United States, 4MR R&D Collaborations, Siemens Healthcare, Atlanta, GA, United States, 5MR R&D Collaborations, Siemens Healthcare, Cary, NC, United States

Diffusion-weighted imaging (DWI) has been shown to have superior tumor-to-tissue contrast for cancer detection in abdominal region. However, the respiratory motion may induce severe imaging errors or artifacts for DWI images. This study aims at developing and evaluating a respiratory correlated 4D-DWI technique using a retrospective sorting method for imaging respiratory motion on human subjects. Comparing to free breathing DWI, 4D-DWI can lead to more accurate measurement of ADC. This has a great potential to improve the visualization and delineation of cancer tumors for radiotherapy.

This abstract and the presentation materials are available to members only; a login is required.

Join Here