Abstract #0632

Apparent diffusion coefficient correlates with gamma oscillation of local field potentials

Tomokazu Tsurugizawa¹, Yoshifumi Abe¹, and Denis Le Bihan¹

¹NeuroSpin, Bât 145, Commissariat à l’Energie Atomique-Saclay Center, 91191, France, Gif-sur-Yvette, France

BOLD fMRI which relies on neurovascular coupling may fail when neurovascular coupling is weakened, such as anesthesia or alcohol intoxication. In contrast, diffusion fMRI has been shown to be more directly linked to neuronal activation even in the absence of neurovascular coupling. We compared BOLD fMRI and diffusion fMRI (ADC) time-courses with local field potentials (LFPs) in rat nucleus accumbens following alcohol stimulation under two different doses of medetomidine anesthesia. The ADC responses were correlated with LFP signals while BOLD signals were not. These results show the interest of diffusion fMRI to avoid confounds from varying conditions of neurovascular coupling.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.