Abstract #0644

Relative latency and temporal variability of BOLD fMRI signal within human visual cortex

Jo-Fu Lotus Lin¹, Jonathan R Polimeni², Wen-Jui Kuo³, and Fa-Hsuan Lin¹

¹Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, ²Athinoula A. Martinos Center, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States, ³Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan

We used inverse imaging to spatiotemporally characterize the relative latency and variability of the BOLD signal at human visual cortex with 0.1 s precision. The relative BOLD latency in the left and right visual cortex was 0.12 (s) +/- 0.33 (s). The BOLD variability in the left and right visual cortex was 0.39 (s) +/- 0.25 (s). Local relative BOLD latency was linearly related to local BOLD variability. The least variability (< 0.2 s) and the earliest onset of the BOLD signal were found at the trough of the calcarine sulcus.

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