Abstract #0646

A 3-Dimensional Microvascular Phantom for Perfusion Imaging

Thomas Gaass^1,2, Moritz Schneider¹, Michael Ingrisch¹, Julia Herzen³, and Julien Dinkel^1,2

¹Institute for Clinical Radiology, Ludwig-Maximilians University, Munich, Germany, ²Comprehensive Pneumology Center, German Center for Lung Research, Munich, Germany, ³Department of Physics, Technische Universität München, Munich, Germany

The presented work demonstrates the applicability of a dedicated 3-dimensional phantom as a realistic MR- and CT-compatible phantom for microvascular perfusion simulation. The device constructed using resin-embedded, melt-spun, sacrificial sugar structures was examined using dynamic contrast enhanced MRI. Parameters, such as flow and volume fraction gained from deconvolving the signal enhancement curve showed very good agreement with the pre-set perfusion parameters. The presented phantom showed great potential in realistically simulating the capillary bed and can potentially serve as a quality insurance device for quantitative dynamic contrast enhanced MRI in the future.

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