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Abstract #0655

A Novel Prostate DCE-MRI Flow Phantom for the Quantitative Evaluation of Pharmacokinetic Parameters

Silvin P. Knight1, Jacinta E. Browne2, James F. Meaney1, David S. Smith3, and Andrew J. Fagan1

1National Centre for Advanced Medical Imaging (CAMI), St James Hospital / School of Medicine, Trinity College University of Dublin, Dublin, Ireland, 2School of Physics, Medical Ultrasound Group, Dublin Institute of Technology, Dublin, Ireland, 3Institute of Imaging Science / Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

A method is lacking to comprehensively validate and optimise the ability of prostate DCE-MRI techniques to accurately measure pharmacokinetic (PK) parameters. We present a novel flow phantom capable of simultaneously producing two measurable, reproducible, and known arbitrarily-shaped contrast time-intensity curves, from which PK parameters can be derived. Ktrans values were derived from MR data acquired at different temporal resolutions (2.3-20.3s) and were found to differ by -8.1% to -44.6%, when compared to calibrated ‘truth estimate’ values, with the lowest variance measured at a temporal resolution of 6.8s. The phantom can be used to help establish robust DCE-MRI prostate protocols.

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