Abstract #0660

Diffusion-Relaxation Correlation Spectroscopic Imaging (DR-CSI): An Enhanced Approach to Imaging Microstructure

Daeun Kim¹, Joong Hee Kim², and Justin P Haldar¹

¹Department of Electrical Engineering, University of Southern California, Los Angeles, CA, United States, ²Department of Neurology, Washington University, St. Louis, MO, United States

We propose a new MR experiment called diffusion-relaxation correlation spectroscopic imaging (DR-CSI). DR-CSI acquires imaging data across a range of different b-value and echo time combinations, and then performs regularized reconstruction to generate a 2D diffusion-relaxation correlation spectrum for every voxel. The peaks of this spectrum correspond to the different tissue microenvironments that are present within each macroscopic imaging voxel, which provides powerful insight into the tissue microstructure. Compared to standard relaxometry or diffusion imaging, DR-CSI provides unique capabilities to resolve tissue compartments that have similar relaxation or diffusion parameters. DR-CSI is demonstrated with spinal cord traumatic injury MRI data.

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