Abstract #0674

Initial experiences of simultaneous in vivo metabolic imaging using MRI, PET, and hyperpolarized 13C MRSI from rat glioma models

JAE MO PARK¹, Shie-Chau Liu¹, Milton Merchant², Taichang Jang², Keshav Datta¹, Praveen Gulaka¹, Zachary Corbin², Ralph E Hurd³, Lawrence Recht², and Daniel M Spielman¹

¹Radiology, Stanford University, Stanford, CA, United States, ²Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States, ³Applied Sciences Laboratory, GE Healthcare, Menlo Park, CA, United States

We demonstrated the feasibility of simultaneous investigation of in vivo metabolism using ¹H MRI, time-of-flight ¹⁸F-FDG PET, and hyperpolarized ¹³C-pyruvate MRSI in C6 xenograft and ENU-induced brain tumor models. Volumetric images were acquired, and metabolic kinetics of FDG and pyruvate metabolism was investigated in the study.

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