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Abstract #0674

Initial experiences of simultaneous in vivo metabolic imaging using MRI, PET, and hyperpolarized 13C MRSI from rat glioma models

JAE MO PARK1, Shie-Chau Liu1, Milton Merchant2, Taichang Jang2, Keshav Datta1, Praveen Gulaka1, Zachary Corbin2, Ralph E Hurd3, Lawrence Recht2, and Daniel M Spielman1

1Radiology, Stanford University, Stanford, CA, United States, 2Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States, 3Applied Sciences Laboratory, GE Healthcare, Menlo Park, CA, United States

We demonstrated the feasibility of simultaneous investigation of in vivo metabolism using 1H MRI, time-of-flight 18F-FDG PET, and hyperpolarized 13C-pyruvate MRSI in C6 xenograft and ENU-induced brain tumor models. Volumetric images were acquired, and metabolic kinetics of FDG and pyruvate metabolism was investigated in the study.

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