Initial experiences of simultaneous in vivo metabolic imaging using MRI, PET, and hyperpolarized 13C MRSI from rat glioma models
JAE MO PARK1, Shie-Chau Liu1, Milton Merchant2, Taichang Jang2, Keshav Datta1, Praveen Gulaka1, Zachary Corbin2, Ralph E Hurd3, Lawrence Recht2, and Daniel M Spielman1
1Radiology, Stanford University, Stanford, CA, United States, 2Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States, 3Applied Sciences Laboratory, GE Healthcare, Menlo Park, CA, United States
We
demonstrated the feasibility of simultaneous investigation of in vivo metabolism using 1H
MRI, time-of-flight 18F-FDG PET, and hyperpolarized 13C-pyruvate
MRSI in C6 xenograft and ENU-induced brain tumor models. Volumetric images were
acquired, and metabolic kinetics of FDG and pyruvate metabolism was
investigated in the study.
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