Abstract #0676

30-Second Bound- and Pore-Water Maps of Cortical Bone

Mary Kate Manhard¹, Kevin D Harkins², Daniel F Gochberg², Jeffry S Nyman³, and Mark D Does¹

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³Department of Orthopaedics & Rehabilitation, Vanderbilt University, Nashville, TN, United States

Imaging bound and pore water concentrations in cortical bone using UTE MRI has shown potential for evaluating fracture risk, but 3D methods require a relatively long scan time (~30 minutes total). 2D UTE with optimized half-pulses was implemented to acquire both bound and pore water maps in ~30 seconds and results were compared to 3D UTE, both ex vivo and in vivo. Mean differences in bound/pore water concentration were less than 10%. Applying these fast sequences in 2D has the potential to greatly increase the utility of these methods in clinical settings for evaluating fracture risk in patient populations.

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