Meeting Banner
Abstract #0676

30-Second Bound- and Pore-Water Maps of Cortical Bone

Mary Kate Manhard1, Kevin D Harkins2, Daniel F Gochberg2, Jeffry S Nyman3, and Mark D Does1

1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 3Department of Orthopaedics & Rehabilitation, Vanderbilt University, Nashville, TN, United States

Imaging bound and pore water concentrations in cortical bone using UTE MRI has shown potential for evaluating fracture risk, but 3D methods require a relatively long scan time (~30 minutes total). 2D UTE with optimized half-pulses was implemented to acquire both bound and pore water maps in ~30 seconds and results were compared to 3D UTE, both ex vivo and in vivo. Mean differences in bound/pore water concentration were less than 10%. Applying these fast sequences in 2D has the potential to greatly increase the utility of these methods in clinical settings for evaluating fracture risk in patient populations.

This abstract and the presentation materials are available to members only; a login is required.

Join Here