Abstract #0687

Connectivity Patterns of Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease

Silvina G Horovitz¹, Nora Vanegas-Arroyave^1,2, Ling Huang², Peter M Lauro², Paul A Taylor^3,4,5, Mark Hallett¹, Kareem A Zaghloul⁶, and Codrin Lungu²

¹Human Motor Control Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, United States, ²Office of the Clinical Director, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, United States, ³Scientific and Statistical Computing Core, National Institutes of Health, Bethesda, MD, United States, ⁴Department of Human Biology, Faculty of Health Sciences, University of Cape Town, MRC/UCT Medical Imaging Research Unit, Cape Town, South Africa, ⁵African Institute for Mathematical Sciences, Muizenberg, South Africa, ⁶Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, United States

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective surgical treatment for Parkinson’s Disease (PD). However, its mechanism is unclear. We have developed a pipeline for processing diffusion tensor imaging (DTI) data in DBS patients, and applied it to analyze 22 PD patients implanted with bilateral STN-DBS. With this approach, we have identified the motor nuclei of the thalamus and the superior frontal cortex as the most common targets and predictors of clinical benefits.

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