Jing Guo1, Stephan Marticorena1, Florian Dittmann1, Andreas Fehlner1, Sebastian Hirsch1, Thomas Fischer1, Jürgen Braun2, and Ingolf Sack1
1Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Department of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany
In vivo assessment
of the renal allograft function post kidney transplantation is challenging. We
here demonstrate that multifrequency MR elastography (MMRE) can detect renal allograft dysfunction with good
diagnostic accuracy (AUROC:0.91 [95% CI 0.80-1.02; p < 0.001]). Renal stiffness is
significantly lower in dysfunctional transplant kidney and correlates moderately with glomerular
filtration rate and resistive index. MMRE may serve as a
non-invasive imaging maker to detect renal allograft dysfunction in an early
stage and to monitor renal allograft function longitudinally.
