Abstract #0710

Reduced susceptibility anisotropy in ischemia reperfusion kidneys: evidence of cellular organization as a source of contrast

Luke Xie¹, Vivian Lee¹, Russell Dibb², Yi Qi², Nian Wang³, G. Allan Johnson², and Chunlei Liu³

¹Radiology, University of Utah, Salt Lake City, UT, United States, ²Center for In Vivo Microscopy, Radiology, Duke University Medical Center, Durham, NC, United States, ³Brain Imaging Analysis Center, Radiology, Duke University Medical Center, Durham, NC, United States

Diffusion tensor imaging (DTI) and susceptibility tensor imaging (STI) can assess the integrity of the nephron where STI provides additional molecular information. STI has demonstrated sensitivity to changes in kidney disease models. The source of susceptibility anisotropy is hypothesized to be the organized tubules, basement membrane, and the organized lipids. Ischemia reperfusion is one particular disease model with well known cellular disorganization in specific nephron segments. In the present study, we applied STI in a model of ischemia perfusion to demonstrate changes in susceptibility anisotropy and to provide additional evidence that the cellular organization is a major contributor.

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