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Abstract #0710

Reduced susceptibility anisotropy in ischemia reperfusion kidneys: evidence of cellular organization as a source of contrast

Luke Xie1, Vivian Lee1, Russell Dibb2, Yi Qi2, Nian Wang3, G. Allan Johnson2, and Chunlei Liu3

1Radiology, University of Utah, Salt Lake City, UT, United States, 2Center for In Vivo Microscopy, Radiology, Duke University Medical Center, Durham, NC, United States, 3Brain Imaging Analysis Center, Radiology, Duke University Medical Center, Durham, NC, United States

Diffusion tensor imaging (DTI) and susceptibility tensor imaging (STI) can assess the integrity of the nephron where STI provides additional molecular information. STI has demonstrated sensitivity to changes in kidney disease models. The source of susceptibility anisotropy is hypothesized to be the organized tubules, basement membrane, and the organized lipids. Ischemia reperfusion is one particular disease model with well known cellular disorganization in specific nephron segments. In the present study, we applied STI in a model of ischemia perfusion to demonstrate changes in susceptibility anisotropy and to provide additional evidence that the cellular organization is a major contributor.

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