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Abstract #0730

Complex congenital heart defects in infants produce lasting decreases in functional network segregation

Vincent Jerome Schmithorst1, Jodie Votava-Smith2, Vince Lee1, Vidya Rajagopalan2, Shaheda Suleiman1, Lisa Paquette2, and Ashok Panigrahy1

1Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 2Children's Hospital of Los Angeles, Los Angeles, CA, United States

We used functional connectivity MRI and graph analysis to investigate the impact of congenital heart disease (CHD) on functional network topology in neonates. Cost-dependent and cost-independent analyses both showed decreases in global segregation (transitivity). The cost-dependent analysis showed a decrease in clustering coefficient (reflective of nodal changes) while the cost-independent analysis showed a decrease in modularity and an increase in participation coefficient (reflective of changed community structure). Minimal differences were seen for CHD patients scanned post-operatively compared to those scanned pre-operatively. Results indicate complex CHD results in lasting changes to functional network topology not ameliorated by the effects of surgery.

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