Abstract #0735

Optimizing unanesthetized cerebral oxygen consumption measures: comparison of MRI and near-infrared spectroscopy (NIRS) approaches in neonates with congenital heart disease

Jeffrey N Stout¹, Silvina Ferradal², Borjan Gagoski², Lilla Zollei³, Divya S Bolar^3,4, Alex Lin⁵, Henry H Cheng⁶, Elfar Adalsteinsson^1,7,8, and Patricia Ellen Grant²

¹Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ²Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Boston, MA, United States, ³Martinos Center for Biomedical Imaging, MGH/Harvard Medical School, Boston, MA, United States, ⁴Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ⁵Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, ⁶Department of Cardiology, Boston Children’s Hospital, Boston, MA, United States, ⁷Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁸Institute for Medical Engineering and Science, Cambridge, MA, United States

Concern for cerebral perfusion in neonates with congenital heart disease (CHD) has driven investigations into cerebral hemodynamics. MRI in combination with bedside NIRS has the potential to provide complementary measures of hemodynamics to guide surgical timing and assess response to surgery. We compare MRI and NIRS measures of cerebral hemodynamics. Modality results compare well to literature studies, but intermodality correlation is limited. Before combining modalities additional studies are needed to better understand why cerebral blood flow and CMRO₂ measures in MRI and NIRS differ.

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