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Abstract #0768

The association between cerebrovascular reactivity and resting-state fMRI connectivity in healthy adults

Ali Golestani1, Jonathan Kwinta1,2, Stephen Strother1,2, Yasha Khatamian1, and Jean Chen1,2

1Rotman Research Institute at Baycrest, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada

Changes in the cerebrovascular reactivity (CVR) in known to alter the amplitude of the task-based blood oxygenation level dependent (BOLD) fMRI signal. The effect of CVR on resting-state functional connectivity however is still unknown. In this study, we altered within-individual CVR by manipulating the end-tidal CO2 (PETCO2) level, and in each PETCO2 level we calculated CVR and resting-state connectivity in the motor and executive control networks. rs-fMRI connectivity is significantly influenced with CVR, irrespective of neural function. The strength of this association varies between motor and executive control networks. This study stresses the importance of vascular measurements to remove biases in interpreting rs-fMRI connectivity.

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