Abstract #0768

The association between cerebrovascular reactivity and resting-state fMRI connectivity in healthy adults

Ali Golestani¹, Jonathan Kwinta^1,2, Stephen Strother^1,2, Yasha Khatamian¹, and Jean Chen^1,2

¹Rotman Research Institute at Baycrest, Toronto, ON, Canada, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada

Changes in the cerebrovascular reactivity (CVR) in known to alter the amplitude of the task-based blood oxygenation level dependent (BOLD) fMRI signal. The effect of CVR on resting-state functional connectivity however is still unknown. In this study, we altered within-individual CVR by manipulating the end-tidal CO₂ (PETCO₂) level, and in each PETCO₂ level we calculated CVR and resting-state connectivity in the motor and executive control networks. rs-fMRI connectivity is significantly influenced with CVR, irrespective of neural function. The strength of this association varies between motor and executive control networks. This study stresses the importance of vascular measurements to remove biases in interpreting rs-fMRI connectivity.

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