Abstract #0773

In Vivo Whole-Brain T1-rho Mapping in evaluation of Mesial Temporal Lobe epilepsy

Xixi Zhao¹, Junling Wang¹, Xiangliang Tan¹, Xiang Xiao¹, Jiajun Zhang¹, Yingjie Mei², Queenie Chan³, and Yikai Xu¹

¹Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, People's Republic of, ²Philips Healthcare, Guangzhou, China, People's Republic of, ³Philips Healthcare, HongKong, China, People's Republic of

In human brain, T1ρ has been proven to be relevant with the macromolecular composition of tissues, and supposed to be sensitive to neuronal degeneration. We used T1rho MR imaging to investigate the variations in T1rho values of subcortical gray matter structures automatic-drawn using FIRST segmentation among temporal lobe epilepsy patients and the underlying relation between the significantly altered T1rho values or volumes of subcortical structures and duration of epilepsy or age at epilepsy onset. Our results demonstrate the feasibility of ROI-wise analysis by atlas-based segmentation of T1rho imaging among mTLE patients

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