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Abstract #0797

Potential application of tissue phase mapping in early detection of heart function deficiency in Fabry disease with cardiac manifestation

Yi-Ting Wu1, Hsu-Hsia Peng2, Meng-Chu Chang2, Ming-Ting Wu3, and Hsiao-Wen Chung1

1Graduate Institute of Biomedical Electronics and Bioinformatics, Taipei, Taiwan, 2Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 3Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Fabry disease is an X chromosome-linked genetic disease that can lead to cardiac dysfunction later in life. For early detection of heart function deficiency, velocity information in the myocardium obtained in a cardiac cycle using MR tissue phase mapping (TPM) can potentially provide a preclinical diagnosis of Fabry cardiomyopathy. Regional MR TPM analysis was performed on 7 Fabry disease patients and 22 healthy subjects. Preliminary results demonstrated significantly delayed time course as well as decreased velocity amplitudes in myocardial contractions in the patients. MR TPM may find useful value in early detection of myocardial defects.

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