Abstract #0803

Imaging Reactive Oxygen Species (ROS) using CEST MRI

Rong-Wen Tain^1,2, Alessandro Scotti^2,3, Weiguo Li^4,5, Xiaohong Joe Zhou^1,2,3,6, and Kejia Cai^1,2,3

¹Radiology, College of Medicine, University of Illinois, Chicago, IL, United States, ²3T Research Program, Center for MR Research, College of Medicine, University of Illinois, Chicago, IL, United States, ³Bioengineering, College of Engineering, University of Illinois, Chicago, IL, United States, ⁴Research Resource Center, University of Illinois, Chicago, IL, United States, ⁵Radiology, Northwestern University, Chicago, IL, United States, ⁶Neurosurgery, College of Medicine, University of Illinois, Chicago, IL, United States

It is extremely challenging to non-invasively measure tissue ROS due to its low concentration and short lifetime. This study aims to demonstrate a fully non-invasive CEST MRI method to measure ROS concentration. CEST Z-spectra were acquired from egg white samples with and without hydrogen peroxide treatment. In addition, proton exchange rate, T₁, and T₂ relaxation time maps were acquired for further clarification on CEST contrast origin. We have demonstrated that ROS is paramagnetic and can greatly enhance proton exchange rate leading to reduced CEST contrast.

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