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Abstract #0815

Hyperpolarized saline for contrast-enhanced MR at Ultra-Low field

Najat Salameh1,2,3, Mathieu Sarracanie1,2,3, Loyd Waites4, David Waddington1,3,5, and Matthew Rosen1,2,3

1MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Department of Physics, Harvard University, Cambridge, MA, United States, 4Rensselaer Polytechnic Institute, Troy, NY, United States, 5ARC Center for Engineered Quantum Systems, School of Physics, University of Sydney, Sydney, Australia

Radiologists routinely use contrast-enhanced MRI with applications mainly in oncology and abdominal imaging. Over the last decade, researchers have put significant efforts in developing new probes for molecular imaging where contrast agents would target only specific cells and/or regions. In all cases, one main question remains: what is the potential toxicity of this new contrast agent? We propose here a safe approach to contrast-enhanced MRI, using pre-polarized biocompatible saline combined with imaging at ultra-low field (0.0065 T).

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