Abstract #0821

Acceleration of 3D UTE Imaging to Quantify Temperature-Dependent T1 Changes in Cortical Bone

Misung Han¹, Wenwen Jiang², Roland Krug¹, Peder Larson^1,2, and Viola Rieke¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Joint Graduate Program in Bioengineering, University of California, San Francisco/Berkeley, San Francisco, CA, United States

High-intensity focused ultrasound (HIFU) is a promising, noninvasive technique to ablate bone tumors and palliate painful bone metastases. During HIFU treatment, temperature mapping is desirable for proper heat deposition to targeted bone regions. Even though conventional PRF-based thermometry cannot be applied for cortical bone due to its short T2 relaxation time, it was demonstrated using 3D UTE imaging can be used to measure T1 changes due to heating. In this work, we accelerated 3D UTE imaging by combining parallel imaging and compressed sensing and compared calculated T1 changes due to heating with those from fully sampled data.

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